Alyssa Milano replaced Lori Rom in the role of Phoebe Halliwell.

The opening theme, "How Soon is Now" is a cover by Love Spit Love of a song by '80s British band The Smiths. It originally appeared in The Craft, also about witches.

In "Primrose Empath", Prue (Shannen Doherty) gains superpowers to fight the demon Vinceres (Morgan Weisser). The fight scene in the manor is very similar of the scene in The Matrix when Neo (Keanu Reeves) fights Agent Smith (Hugo Weaving) in the railway station.

The house used for the exterior shots of the "Manor" is located at 1329 Carroll Ave in the Echo Park Section of Los Angeles.

At the end of Season three, Shannen Doherty quit. At the same time WB announced they will pick up Charmed for the next three years

In June 2001, Executive Producer, Aaron Spelling announced after several auditions and many considered actresses (including Jennifer Love Hewitt, Sarah Brown, Tiffani Thiessen, Soleil Moon Frye, Susan Ward and Eliza Dushku) that Rose McGowan had won the role of Paige Matthews, the long-lost, baby half-sister of Prue, Piper and Phoebe.

Brian Krause originally auditioned for the role of Andy

Actor Kerr Smith who appears in season seven as Agent Brody actually auditioned for the role of Inspector Andy Trudeau, who was a character played in season one by actor Ted King.

Beginning with season seven, the Charmed set moved from its previously smaller Canoga Park, California studio lot to the more grand scale Paramount Studios lot.

The character Phoebe didn't own a car of her own until season five. Before then she either rode her bike, used public transport, or had to ask her sisters for transportation.

The Book of Shadows weighs 9 pounds, 6 ounces and is the most valuable thing on set.

The actress with the most Charmed Fan Mail is actually not one of the main stars of the show. Actress Finola Hughes who plays Prue, Piper, Phoebe and Paige's mother receives the most fan mail from Charmed series viewers.

The Book of Shadows is almost entirely hand-painted.

Alyssa Milano liked the drawings made for the Book of Shadows so much that she had the artist paint murals on her walls at home.

In the pilot episode, toward the end of the show, Shannen Doherty picks up a newspaper from the sidewalk. The newspaper headline reads "Firemen Doubt Fire was Accidental", the same newspaper prop used in Mrs. Doubtfire.

Until the appearance of Chris Perry in the fifth season finale episode "Oh My Goddess", the only male witches shown on the series have all been children.

In the episode "Chick Flick", the movie where Billy comes out of, is the same movie Phoebe is watching in the episode "Sense and Sense Ability". Where she is turning the television up. The movie was also used in the episode "Bride And Gloom".

During the first few seasons when Constance M. Burge was Executive Producer the series had more focus on the girl's sisterly ties and discovering their witchly heritage. That changed when the show's reigns were handed over to Producer Brad Kern and the focus shifted more to vampy outfits and consistent relationship issues.

The make-up design for the demon Balthezor was based on the same make-up style used for the character of Darth Maul in Star Wars: Episode I - The Phantom Menace.

At the end of each season we see a set of doors close. The first two seasons ended with Prue using her telekinetic powers to close the Manor's entrance doors. Season three showed the demon Shax slamming the doors shut with wind, causing the door's glass to shatter. Season four had the Angel of Destiny magically close the doors after Piper discovers she is pregnate. Season five had Piper and Leo's son Chris telekinetically shut the doors ala Prue. Season six showed the doors to a hospital room shut magically after Piper's second child is born.

Originally the role of Bane Jessup played by Antonio Sabato Jr. in episode "Ms. Hellfire" was supposed to be filled by actor Richard Grieco but Charmed actress/producer Shannen Doherty objected to the casting and was quickly supported in that decision by fellow stars Alyssa Milano and Holly Marie Combs.

The show's popularity inspired toy company SOTA Toys to create 6.5" action figures of the characters: Piper, Phoebe, Paige and Balthezor which come with interlocking attic walls and a miniature Book of Shadows. Originally an alternate toy of the Prue character was to be made, but actress Shannen Doherty declined to have her likeness be made for a Charmed doll.

In “Charmed and Dangerous”, there were more scenes. The scene where Piper was writing her will was longer. It included a part where Leo asks what he is going to do with the book of shadows, and Piper tells him to give it to one of his charges. There was also a scene where Phoebe and Cole are writing the spell to vanquish the Source. In Witch Way Now, there was a deleted scene where Leo and Darryl searched the witch hunter's office and they got caught.

The original ending of “Oh My Goddess Part 2” did not end with Chris waving his hand and Leo blowing up. It originally showed Chris waving his hand and Leo disappeared and you see him in a cage in Valhalla.

The syndicated airings on TNT are cut by a little bit. It is most noticeable in episode the first season finale, when we hear the sisters calling Prue's name when she's unconsious, and in the third episode of season three, when they freeze Kate's parents.